The Spiders' need to dust themselves off quickly as the next game is against local rival VCU.
La Salle had no answers to Richmond's defense but showed brief signs of life in the second half.
The man of the match was freshman guard Bones Hyland who sank 5-of-6 three-pointers and ended up with a career-high 21 points.
VCU defeated Fordham 64 to 46 with a stifling defence.
Spider nabbed their seventh straight victory at home on Saturday night.
The Spiders easily take care of the visitors from South Alabama with a strong second half.
The Rams dominated the Eagles and have improved their record to five straight wins.
Thirteen was the lucky number for the Spiders as they scored 13 in OT to edge out Vanderbilt by 1 point.
North Texas turned the ball over 18 times and fell 3 points short against VCU.
There was no lack of excitement in the Robins Center last night as the Spiders clawed their way to victory in an overtime victory.